Diabetes is classified into two major types: Type 1 (insulin-dependent) diabetes, and Type 2 diabetes. However, it is apparent that there are some forms of the condition which do not fit comfortably into these categories. Indeed, there is one form of diabetes which appears to straddle the two major types. While it appears to affect adults with Type 2 diabetes, it shows many of the genetic, immune, and metabolic features of Type 1 diabetes, and carries a high risk of progression to insulin dependency. This form of the condition is known as 'latent autoimmune diabetes in adults' (LADA). It is found in about 10% of initially non-insulin-requiring people with diabetes, and is therefore probably more prevalent than Type 1 diabetes. A major European Union initiative (ACTIONLADA) plans to learn more about LADA.
LADA, latent autoimmune diabetes in adults, ACTIONLADA, self-antibodies, GAD, insulin, metformin