Pancreas and islet transplantation in the management of diabetes

The relative roles of pancreas transplantation and islet transplantation in the management of diabetes are perhaps best examined in the context of the American Diabetes Association (ADA) position statement - revised in 2003. Given the growing success of islet transplantation, it seems worthwhile to examine whether the ADA recommendations should be reconsidered. In this article, R Paul Robertson compares the proven benefits of pancreas and islet transplantation in the context of five major problems faced by people with diabetes: high blood sugar (hyperglycaemia), low blood sugar (hypoglycaemia) with poor symptom recognition, micro- and macrovascular complications of diabetes, poor quality of life, and autonomic dysfunction (including symptoms such as gastroparesis, low blood pressure episodes, and diabetes-related diarrhoea).
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Keywords: 
transplant, transplantation, pancreas, islet, kidney, nephropathy