If insulin is such an effective drug, why are so many people with type 2 diabetes reluctant to take it, and sometimes really apprehensive, despite acknowledged poor outcomes on diet and oral blood glucose lowering agents? Are healthcare providers part of the problem? Is there such syndrome as Insulin Resistance (PIR)? For a better understanding of PIR, which is commonly observed as a problem in type 2 diabetes, we need to look beyond the demonstrated efficacy of insulin, and understand people’s beliefs, emotions and concerns regarding insulin treatment.