Diabetes has become an important cause of death and disability in the Americas and worldwide. In the region comprising South America, Central America and the Caribbean, and North America, the number of people with diabetes is expected to rise from 13 million to 33 million by 2030. An even more marked increase is set to occur in Latin America and the Caribbean, where most of the nations are considered to be developing countries. This rising prevalence of diabetes is already having grave effects on societies, and women throughout the continent are baring the brunt of the pandemic. The authors look at gender issues relating to the status and impact of diabetes in the Americas and make a call for increased attention to women’s social and health needs.