Eating is a pleasant necessity for most of us. We eat our food, the gastro-intestinal tract (gut) directs nutrients to the blood stream, and excess energy is stored for later use. Much of what is known about the mechanisms that regulate these processes has been learned from diabetes research. Because diabetes has always been regarded as a disease of glucose metabolism, the research has been focussed on the intake and processing of glucose. Jacqueline Dekker looks at the role of fats (lipids) in the processes that give rise to diabetes-related risk factors for cardiovascular disease (CVD).