Research and studies


Growth hormone: a potential treatment option in diabetes?

Despite major fluctuations in supply and demand, sophisticated mechanisms in the body maintain levels of blood sugar (glucose) within narrow limits. Although under normal conditions, insulin is the major regulator of blood glucose levels, growth hormone (GH) and insulin-like growth factor-1 (IGF-1) play an important contributory role. Both of these hormones have potent effects on glucose metabolism which may be utilized in diabetes management. Richard Holt explains the growing interest in exploiting the effects of GH and IGF-1 for people with diabetes.

Computer-simulated modelling in the management of diabetes

Diabetes has many complications which can take decades to develop. Scores of therapies are now available for the prevention of Type 2 diabetes, and the complications of diabete. People with diabetes vary widely in their risks and histories of diabetes-related complications. How, then, can we choose from the many treatment options which are currently on offer to people with the condition?

Pancreas and islet transplantation in the management of diabetes

The relative roles of pancreas transplantation and islet transplantation in the management of diabetes are perhaps best examined in the context of the American Diabetes Association (ADA) position statement - revised in 2003. Given the growing success of islet transplantation, it seems worthwhile to examine whether the ADA recommendations should be reconsidered.

Improving diabetes therapy: improving satisfaction

Research advances in diabetes have led to increased therapeutic options for people with the condition. This has led to increasing levels of satisfaction among the consumers of these treatment options – people with diabetes. One aspect of satisfaction deals specifically with the person's evaluation of medical treatments. Treatment satisfaction

Towards an understanding of the genetic causes of diabetes

People develop Type 1 diabetes when their immune system specifically seeks out and destroys the insulin-producing ß-cells in their pancreas. The interaction of environmental factors with a number of gene variants results in the immune disturbance which causes the condition. In this article, Tony Merriman looks at the approaches used to identify the genes which make a person susceptible to Type 1 diabetes.

Latent autoimmune diabetes in adults (LADA)

Diabetes is classified into two major types: Type 1 (insulin-dependent) diabetes, and Type 2 diabetes. However, it is apparent that there are some forms of the condition which do not fit comfortably into these categories. Indeed, there is one form of diabetes which appears to straddle the two major types. While it appears to affect adults with Type 2 diabetes, it shows many of the genetic, immune, and metabolic features of Type 1 diabetes, and carries a high risk of progression to insulin dependency. This form of the condition is known as 'latent autoimmune diabetes in adults' (LADA).

Detect-2: early detection of type 2 diabetes and IGT

Type 2 diabetes has reached pandemic levels, with the global number of people with the condition predicted to exceed 330 million by 2025. Overall, at least 50% of those with diabetes presently do not know that they have the condition. In developing countries the proportion with undiagnosed diabetes is considerably higher. At the time of clinical diagnosis, every second person with diabetes has already developed one or more micro- or macrovascular complications.