Submitted by Lorenzo.Piemonte on Thu, 07/07/2011 - 13:30
people with diabetes constantly walk a tight rope between strict glucose control to prevent complications and hypoglycaemia. Too often, slight miscalculations result in hypoglycaemia, which can be at best embarrassing and irritating, and may cause injury or even death.
Submitted by Lorenzo.Piemonte on Thu, 07/07/2011 - 11:57
Type 2 diabetes is a heterogeneous disease characterized by multiple pathogenic defects. Impaired insulin secretion and insulin action (insulin resistance) are well-recognized major mechanisms contributing to the development of diabetes. In the past years, intensive research has much improved our understanding of the molecular mechanisms leading to defects of beta-cell function and impaired ability of insulin to promote glucose uptake in muscle and adipose tissue. More recently, other organs have been shown to play a role in the abnormalities of glucose homeostasis.